WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Axon guidance       ID:04360
C=129; O=4; E=0.31; R=12.98; rawP=0.0003; adjP=0.0069
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000135333 NA EPHA7 EPH receptor A7 2045 ENSG00000135333
2  ENSG00000112902 NA SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 9037 ENSG00000112902
3  ENSG00000116106 NA EPHA4 EPH receptor A4 2043 ENSG00000116106
4  ENSG00000076356 NA PLXNA2 plexin A2 5362 ENSG00000076356


Database:KEGG pathway       Name:Phosphatidylinositol signaling system       ID:04070
C=78; O=3; E=0.19; R=16.10; rawP=0.0009; adjP=0.0075
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000040933 NA INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 3631 ENSG00000040933
2  ENSG00000058866 NA DGKG diacylglycerol kinase, gamma 90kDa 1608 ENSG00000058866
3  ENSG00000157680 NA DGKI diacylglycerol kinase, iota 9162 ENSG00000157680


Database:KEGG pathway       Name:ErbB signaling pathway       ID:04012
C=87; O=3; E=0.21; R=14.44; rawP=0.0012; adjP=0.0075
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000177885 NA GRB2 growth factor receptor-bound protein 2 2885 ENSG00000177885
2  ENSG00000157168 NA NRG1 neuregulin 1 3084 ENSG00000157168
3  ENSG00000185634 NA SHC4 SHC (Src homology 2 domain containing) family, member 4 399694 ENSG00000185634


Database:KEGG pathway       Name:Gap junction       ID:04540
C=90; O=3; E=0.21; R=13.96; rawP=0.0013; adjP=0.0075
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000177885 NA GRB2 growth factor receptor-bound protein 2 2885 ENSG00000177885
2  ENSG00000061918 NA GUCY1B3 guanylate cyclase 1, soluble, beta 3 2983 ENSG00000061918
3  ENSG00000043591 NA ADRB1 adrenoceptor beta 1 153 ENSG00000043591


Database:KEGG pathway       Name:Neuroactive ligand-receptor interaction       ID:04080
C=272; O=4; E=0.65; R=6.16; rawP=0.0042; adjP=0.0193
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000108405 NA P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1 5023 ENSG00000108405
2  ENSG00000108556 NA CHRNE cholinergic receptor, nicotinic, epsilon (muscle) 1145 ENSG00000108556
3  ENSG00000164270 NA HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3360 ENSG00000164270
4  ENSG00000043591 NA ADRB1 adrenoceptor beta 1 153 ENSG00000043591


Database:KEGG pathway       Name:Glycerolipid metabolism       ID:00561
C=50; O=2; E=0.12; R=16.75; rawP=0.0064; adjP=0.0245
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000058866 NA DGKG diacylglycerol kinase, gamma 90kDa 1608 ENSG00000058866
2  ENSG00000157680 NA DGKI diacylglycerol kinase, iota 9162 ENSG00000157680


Database:KEGG pathway       Name:Glioma       ID:05214
C=65; O=2; E=0.16; R=12.88; rawP=0.0107; adjP=0.0246
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000177885 NA GRB2 growth factor receptor-bound protein 2 2885 ENSG00000177885
2  ENSG00000185634 NA SHC4 SHC (Src homology 2 domain containing) family, member 4 399694 ENSG00000185634


Database:KEGG pathway       Name:Calcium signaling pathway       ID:04020
C=177; O=3; E=0.42; R=7.10; rawP=0.0089; adjP=0.0246
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000108405 NA P2RX1 purinergic receptor P2X, ligand-gated ion channel, 1 5023 ENSG00000108405
2  ENSG00000164270 NA HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3360 ENSG00000164270
3  ENSG00000043591 NA ADRB1 adrenoceptor beta 1 153 ENSG00000043591


Database:KEGG pathway       Name:Non-small cell lung cancer       ID:05223
C=54; O=2; E=0.13; R=15.51; rawP=0.0075; adjP=0.0246
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000177885 NA GRB2 growth factor receptor-bound protein 2 2885 ENSG00000177885
2  ENSG00000143171 NA RXRG retinoid X receptor, gamma 6258 ENSG00000143171


Database:KEGG pathway       Name:Chemokine signaling pathway       ID:04062
C=189; O=3; E=0.45; R=6.65; rawP=0.0106; adjP=0.0246
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000177885 NA GRB2 growth factor receptor-bound protein 2 2885 ENSG00000177885
2  ENSG00000167414 NA GNG8 guanine nucleotide binding protein (G protein), gamma 8 94235 ENSG00000167414
3  ENSG00000185634 NA SHC4 SHC (Src homology 2 domain containing) family, member 4 399694 ENSG00000185634




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).